Pathological Fracture of the Tibia as a First Sign of Hyperparathyroidism – A Case Report and Systematic Review of the Current Literature

Background/Aim: Pathological fractures are rare, suspicious and in some cases mentioned as the first sign of a malignant tumor. We present an uncommon case with pathological fracture tibia diaphysis severe hyperparathyroidism. Case Report: report female patient who was referred to emergency department history progressively worsening pain lower left leg inability fully bear weight. No trauma or any other injury reported. An x-ray revealed extensive osteolytic lesion tibial shaft cortical bone destruction. Conclusion: Our case, together very few described current literature, emphasizes that presence hypercalcemia lytic lesions primary hyperparathyroidism should always be considered differential diagnosis. Lytic can lead impairment quality life.